Compound 20 Chemical Structure, oral α5-GABAA receptor NAM - Gedeon Richter, Budapest, HU

oral α5-GABAA receptor NAM

oral efficacy in CIAS rodent models

scaffold hopping from literature starting point

J. Med. Chem.

Gedeon Richter, Budapest, HU

Context. “Compound 20” (Gedeon Richter) is an oral α5-GABAA receptor negative allosteric modulator (NAM) being developed for cognitive disorders. GABA receptor NAMs are known to exert effects opposite to…


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