oral α5-GABAA receptor NAM

oral efficacy in CIAS rodent models

scaffold hopping from literature starting point

J. Med. Chem.

Gedeon Richter, Budapest, HU

Compound 20 Chemical Structure, oral α5-GABAA receptor NAM - Gedeon Richter, Budapest, HU

Context. “Compound 20” (Gedeon Richter) is an oral α5-GABAA receptor negative allosteric modulator (NAM) being developed for cognitive disorders. GABA receptor NAMs are known to exert effects opposite to…


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