3 minute read
Jun. 18, 2022

An Oral α5-GABA A Receptor Negative Allosteric Modulator (NAM)

compound 20

oral α5-GABAA receptor NAM oral efficacy in CIAS rodent models scaffold hopping from literature starting point J. Med. Chem., May 18, 2022 Gedeon Richter, Budapest, HU

Drug Hunter Team

“Compound 20” (Gedeon Richter) is an oral α5-GABA A receptor negative allosteric modulator (NAM) being developed for cognitive disorders . GABA receptor NAMs are known to exert effects opposite to the anxiolytic and anticonvulsant effects of positive allosteric modulators. However, NAM agents targeting α5-GABA A receptors, which have [...]



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