TEAD transcription factor lipidation modulator

orally active in xenograft model

from 1M cmpd biochemical HTS and opt.

Cell Reports, Jun. 23, 2020

Genentech, South San Francisco, CA

Structure of compound 2

“Compound 2” binds to a lipid pocket on TEAD transcription factors, transforming TEAD from a transcriptional co-activator to a dominant-negative transcriptional repressor of Hippo pathway signaling. The tool molecule demonstrates…


get free samples and a Premium trial

Premium members get access to our library of hundreds of in-depth reviews on key molecules, ten new reviews each month, novel drug approval coverage, drug discovery company updates, and more: