molecules of the month

“Compound 2”

TEAD transcription factor lipidation modulator

orally active in xenograft model

from 1M cmpd biochemical HTS and opt.

Cell Reports, Jun. 23, 2020

Genentech, South San Francisco, CA

Structure of compound 2
1 min read

“Compound 2” binds to a lipid pocket on TEAD transcription factors, transforming TEAD from a transcriptional co-activator to a dominant-negative transcriptional repressor of Hippo pathway signaling. The tool molecule demonstrates activity against xenograft models, and will be useful for understanding Hippo pathway biology.

request a trial

You don’t have time to read everything, but you can’t afford to fall behind.

Drug Hunter Premium is drug discovery, distilled, so you can quickly catch up and make informed decisions based on industry examples.

Get ahead now by requesting a trial.

already a member? log in: