2 minute read
Mar. 12, 2022

An Oral ChemR23 Inhibitor from Kyowa Kirin

compound 14f

oral ChemR23 inhibitor Preclinical, immunology from HTS, scaffold hopping and opt. Bioorg. Med. Chem. Kyowa Kirin

Drug Hunter Team

Compound 14f (Kyowa Kirin) is an oral ChemR23 inhibitor with two acidic sites. Nominated by Bryan McKibben , this article describes a scaffold hopping exercise to address the short half-life of previously described chemical matter, and the successful development of in-vivo tool inhibitors to probe ChemR23 biology in animal models of [...]



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