Compound 14f (Kyowa Kirin) is an oral ChemR23 inhibitor with two acidic sites. Nominated by Bryan McKibben , this article describes a scaffold hopping exercise to address the short half-life of previously described chemical matter, and the successful development of in-vivo tool inhibitors to probe ChemR23 biology in animal models of [...]
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Mar. 12, 2022
An Oral ChemR23 Inhibitor from Kyowa Kirin
compound 14f
oral ChemR23 inhibitor Preclinical, immunology from HTS, scaffold hopping and opt. Bioorg. Med. Chem. Kyowa Kirin
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