oral ChemR23 inhibitor - Kyowa Kirin

oral ChemR23 inhibitor

Preclinical, immunology

from HTS, scaffold hopping and opt.

Bioorg. Med. Chem.

Kyowa Kirin

Context. Compound 14f (Kyowa Kirin) is an oral ChemR23 inhibitor with two acidic sites. Nominated by Bryan McKibben, this article describes a scaffold hopping exercise to address the short…


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