4 minute read
Aug. 26, 2022

Compound 14: a Nicotinamide N-Methyltransferase (NNMT) Inhibitor

compound 14

elective NNMT inhibitor 100-times higher inhibitory activity than original peptide peptide library screening, de novo design and SBDD J. Med. Chem., July 29, 2022 Shionogi Pharmaceutical Research Center, Toyonaka, JP

Drug Hunter Team

“ Compound 14 ” (Shionogi Pharmaceuticals) is a nicotinamide N -methyltransferase (NNMT) inhibitor. For some “difficult to drug” targets such as protein-protein interactions , peptides are attractive therapeutic modalities due to their high binding specificity and synthetic accessibility. Macrocyclization of peptides may help improve [...]



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