Compound 14 Chemical Structure elective NNMT inhibitor - Shionogi Pharmaceutical Research Center, Toyonaka, JP

elective NNMT inhibitor

100-times higher inhibitory activity than original peptide

peptide library screening, de novo design and SBDD

J. Med. Chem.

Shionogi Pharmaceutical Research Center, Toyonaka, JP

Context. “Compound 14” (Shionogi Pharmaceuticals) is a nicotinamide N-methyltransferase (NNMT) inhibitor. For some “difficult to drug” targets such as protein-protein interactions, peptides are attractive therapeutic modalities due to their…


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