TNF_ allosteric inh. (asym. trimer stabilizer)

oral eff. In arthritis model similar to biologic

from 18k cmpd 2D NMR frag. screen + SBDD

J. Med. Chem., Dec. 30, 2020

AbbVie, North Chicago, IL / Worchester, MA

Structure of compound 12

AbbVie selective TNFα allosteric inhibitor

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