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TNF_ allosteric inh. (asym. trimer stabilizer)
oral eff. In arthritis model similar to biologic
from 18k cmpd 2D NMR frag. screen + SBDD
J. Med. Chem., Dec. 30, 2020
AbbVie, North Chicago, IL / Worchester, MA
AbbVie selective TNFα allosteric inhibitor
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