TNF_ allosteric inh. (asym. trimer stabilizer)
oral eff. In arthritis model similar to biologic
from 18k cmpd 2D NMR frag. screen + SBDD
J. Med. Chem., Dec. 30, 2020
AbbVie, North Chicago, IL / Worchester, MA
“compound 12”
1 min read
AbbVie selective TNFα allosteric inhibitor
Search By Structure
- OI338
- PF07059013
- AZD0364
- PF-06843195
- TP0586352
- AZD4573
- “compound 42”
- “compound 12”
- BMS-986202
- pamiparib
- linrodostat
- SAR439859
- ACT-1004-1239
- “compound 1”
Molecules of the Month
2023
2022
2021
2020