XIAP E3-ligase degrader via SM ubiquitylation

novel mechanism of induced degradation

from derivatization of XIAP-binder

Journal of the American Chemical Society

Genentech, San Francisco, US

Chemical structure of compound 10 Genentech XIAP E3-ligase degrader

The Genentech XIAP E3-ligase degrader, compound 10, has an interesting mechanism of action, triggering the degradation of its target (XIAP) by ubiquitylation of the small molecule. The molecule behaves as…


get free samples and a Premium trial

Premium members get access to our library of hundreds of in-depth reviews on key molecules, ten new reviews each month, novel drug approval coverage, drug discovery company updates, and more: