© Rosalind Scientific LLC 2018-2022
© Rosalind Scientific LLC, 2018-2022
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XIAP E3-ligase degrader via SM ubiquitylation
novel mechanism of induced degradation
from derivatization of XIAP-binder
Journal of the American Chemical Society
Genentech, San Francisco, US
The Genentech XIAP E3-ligase degrader, compound 10, has an interesting mechanism of action, triggering the degradation of its target (XIAP) by ubiquitylation of the small molecule. The molecule behaves as…
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