gut-restricted, selective COX-2 inhibitor
in vivo showed no inhibition of gut COX-2
from modification of etoricoxib
Journal of Medicinal Chemistry
Janssen, Spring House, US
“Compound 10”
The Janssen gut-restricted COX-2 inhibitor, compound 10, is a tool compound used to test the hypothesis that gut-restricted COX-2 inhibition would be beneficial for cancer without the cardiovascular risk of…