class I sel. histone deacetylase (HDAC) inhib.

in vitro HIV reactivation for HIV eradication

from structure-based design of prior ligand

ACS Med. Chem. Lett., Jun. 22, 2020

Merck & Co., Kenilworth, NJ / West Point

“Compound 10” is a potent and selective inhibitor of Class I histone deacetylases (HDAC1/2/3) which increases HIV activity in treatment-suppressed patient immune cells for the goal of eradicating HIV from…


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