class I sel. histone deacetylase (HDAC) inhib.
in vitro HIV reactivation for HIV eradication
from structure-based design of prior ligand
ACS Med. Chem. Lett., Jun. 22, 2020
Merck & Co., Kenilworth, NJ / West Point
“Compound 10” is a potent and selective inhibitor of Class I histone deacetylases (HDAC1/2/3) which increases HIV activity in treatment-suppressed patient immune cells for the goal of eradicating HIV from…