Structure of compound 10

class I sel. histone deacetylase (HDAC) inhib.

in vitro HIV reactivation for HIV eradication

from structure-based design of prior ligand

ACS Med. Chem. Lett., Jun. 22, 2020

Merck & Co., Kenilworth, NJ / West Point

“Compound 10” is a potent and selective inhibitor of Class I histone deacetylases (HDAC1/2/3) which increases HIV activity in treatment-suppressed patient immune cells for the goal of eradicating HIV from…

 this content is exclusive to
Premium members

Unlock this content with a Premium membership to read it now.