selective oral ATR kinase inhibitor

in Ph. I for adv. solid tumors and lymphomas

from HTS and modeling on PI3Kg structure

J. Med. Chem., Jun. 5, 2020

Bayer AG, Berlin, DE

Structure of ATR inhibitor BAY 1895344

BAY 1895344 is a potent and highly selective inhibitor of the ATR kinase, which is involved in the DNA damage response. Further disruption of the DNA damage response via ATR…

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