non-steroid glucocorticoid receptor modulator
completed Ph. I as topical agent in psoriasis
from optimization of prior lead
Bioorg. Med. Chem. Lett., Jun. 1, 2020
Bayer AG, Berlin, DE / AstraZeneca
BAY 1003803
BAY 1003803 is a potent topical agonist of the glucocorticoid receptor (GR) transrepression pathway, with less activity on the GR transactivation pathway mediated by GR dimers, which may lead to…