non-steroid glucocorticoid receptor modulator

completed Ph. I as topical agent in psoriasis

from optimization of prior lead

Bioorg. Med. Chem. Lett., Jun. 1, 2020

Bayer AG, Berlin, DE / AstraZeneca

Structure of glucocorticoid receptor agonist BAY 1003803

BAY 1003803 is a potent topical agonist of the glucocorticoid receptor (GR) transrepression pathway, with less activity on the GR transactivation pathway mediated by GR dimers, which may lead to…

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