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Managing Toxicity Liabilities in a Novel Chemotype of NLRP3 Inflammasome Inhibitors

AZD4144

oral NLRP3 inflammasome inhibitor Ph. I in healthy volunteers from HTS measuring IL-1β release in THP-1 cells EFMC-ISMC 2024 Meeting First Time Disclosures AstraZeneca, Mölndal, SE/Mitsubishi Tanabe, Yokohama, JP

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