non-immunosuppressive cyclophilin inhibitor
oral activity in humanized HCV model
from semisynthetic deriv. of FR901459
Bioorg. Med. Chem. Lett., Jun. 2, 2020
Astellas Pharma, Ibaraki, JP
ASP5286
ASP5286 is an analog of the natural product cyclosporin A that maintains the anti-HCV activity of cyclosporin A by binding to cyclophilin, but was optimized to be less immunosuppresive than…