Structure of ASP-5286

non-immunosuppressive cyclophilin inhibitor

oral activity in humanized HCV model

from semisynthetic deriv. of FR901459

Bioorg. Med. Chem. Lett., Jun. 2, 2020

Astellas Pharma, Ibaraki, JP

ASP5286 is an analog of the natural product cyclosporin A that maintains the anti-HCV activity of cyclosporin A by binding to cyclophilin, but was optimized to be less immunosuppresive than…

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