MRTX1133 Mirati G12D inhibitor chemical structure drug hunter molecules of the year kras

reversible KRASG12D inhibitor

preclinical efficacy in cancer model

from SBDD around KRASG12C inhibitor

MRTX1133

Mirati Therapeutics, San Diego, CA

MRTX1133 was nominated as December 2021’s cover molecule by reviewers Joachim Rudolph and Julien Lefranc. MRTX1133 is a non-covalent inhibitor of KRASG12D that demonstrated tumor regression in a mouse…


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