GLP-1R/GLP molecular glue agonist (PAM)
oral blood glucose↓, additive w/ sitaglipin
from 220k cmpd cell-based screen + PK opt.
J. Med. Chem., Mar. 15, 2021
Lilly Research Laboratories, Indianapolis, IN
LSN3318839
1.The Lilly glucagon-like peptide-1 receptor (GLP-1R) agonist (LSN3318839) is a positive allosteric modulator intended to treat type 2 diabetes. This drug candidate has an interesting proposed mechanism as a…