LSN3318839

GLP-1R/GLP molecular glue agonist (PAM)

oral blood glucose↓, additive w/ sitaglipin

from 220k cmpd cell-based screen + PK opt.

J. Med. Chem., Mar. 15, 2021

Lilly Research Laboratories, Indianapolis, IN

1.The Lilly glucagon-like peptide-1 receptor (GLP-1R) agonist (LSN3318839) is a positive allosteric modulator intended to treat type 2 diabetes. This drug candidate has an interesting proposed mechanism as a…


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