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Jan. 17, 2022

HR011303 is a URAT1 Inhibitor for Gout


human uric acid transporter inhibitor phase III candidate for hyperuricemia and gout from pharmacophore-based lead generation Drug Metabolism and Disposition Jiangsu Hengrui Medicine Co., Shanghai, CN

Drug Hunter Team

Gout is caused by the buildup of uric acid. The main treatments are drugs that increase uric acid secretion (uricosurics, e.g. probenecid ) and xanthine oxidase inhibitors which inhibit uric acid production (e.g. allopurinol ). URAT1 inhibitors like lesinurad (Ironwood Pharmaceuticals) and dotinurad are emerging treatments, inhibiting uric [...]



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