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zinc-binding ADAMTS-5 metalloproteinase inh.
oral candidate in Ph. II for osteoarthritis
50k cmpd HTS enriched for zinc-binding + opt.
J. Med. Chem., Mar. 15, 2021
Galapagos SASU, FR / Servier, FR
The Galapagos-Servier selective ADAMTS-5 metalloproteinase inhibitor (GLPG1972) recently completed a Ph. II study for knee osteoarthritis. Identification of small molecule clinical candidates for metalloproteinases is challenging due to selectivity…
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