Structure of GDC-0310

zwitterionic oral selective Nav1.7 inh. for pain

predicted QD dosing, completed Ph. I, discont.

PK optimization of prior scaffold

J. Med. Chem., Mar. 8, 2021

Genentech, South San Francisco, CA / Xenon

The Genentech Nav1.7 inhibitor (GDC-0310) is a oral Ph. I clinical candidate for pain. Nav1.7 has been a hot target for pain, and we previously highlighted a Nav1.7 inhibitor…

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