gut-restrict. P-gp inh. for oral paclitaxel combo

efficacious in Ph. III, NDA filed but CRL issued

from opt. of tariquidar

J. Med. Chem., Mar. 17, 2021

Athenex / Hanmi Pharmaceutical, Seoul, KR

The Athenex/Hanmi Pharmaceutical P‑gp transporter inhibitor (encequidar) is a gut-restricted compound intended to reduce efflux and increase absorption of the IV drug, paclitaxel to enable oral paclitaxel delivery.  The…

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