CNS pen. GPR6 GPCR inverse agonist

oral QD Ph. II candidate for ParkinsonÕs

from 360k cmpd cell-based HTS + opt.

J. Pharmacol. Exp. Ther., Apr. 1, 2021

Cerevance / Takeda California, San Diego, US

Structure of CVN424

The Cerevance/Takeda GPR6 inverse agonist (CVN424) is an oral, once-daily clinical candidate in Ph. II for Parkinson’s disease after completing a Ph. I in healthy volunteers. Its >40 µM…

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