Chemical structure of molecule compound 54c

inhaled JAK inhibitor

reduced AO metabolism in lung

from kinase-focused screening and SBDD

Journal of Medicinal Chemistry

GlaxoSmithKline, Stevenage, UK

JAK kinases are now well-established targets in immunology, but the class has always had safety concerns hanging over it. The safety issues were exacerbated by a recent FDA decision…

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