Chemical structure of molecule compound 3 Vanin-1

vanin-1 pantetheinase inhibitor

preclinical candidate for IBD

from HTS + SBDD

Journal of Medicinal Chemistry

Pfizer, Cambridge, MA + Groton, CT

Vanin-1 is a biotinidase (nitrilase superfamily) that hydrolyzes pantetheine. Despite the critical role of pantetheine, vanin-1 deficient mice don’t appear to have issues, but may be protected in inflammatory…

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