Chemical structure of molecule compound 22 CNS-penetrant ELOVL1 inhibitor

ELOVL1 fatty acid elongase inhibitor

on-target toxicity suggested

from HTS and property-based optimization

Journal of Medicinal Chemistry

Vertex, Boston, MA

Vertex recently disclosed a CNS-penetrant ELOVL1 inhibitor, in which they described preclinical safety findings in rat and cyno. In this article, they disclose a structurally distinct series which displayed…


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