Chemical structure of molecule compound 22 CNS-penetrant ELOVL1 inhibitor

ELOVL1 fatty acid elongase inhibitor

on-target toxicity suggested

from HTS and property-based optimization

Journal of Medicinal Chemistry

Vertex, Boston, MA

Vertex recently disclosed a CNS-penetrant ELOVL1 inhibitor, in which they described preclinical safety findings in rat and cyno. In this article, they disclose a structurally distinct series which displayed…

 this content is exclusive to
Premium members

Upgrade to a Premium Drug Hunter membership to unlock the full content and start reading now.