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“Compound 20”

Recent Publication

cryo-EM-characterized TRPA1 ion channel inh.

oral efficacy (10 mpk BID) in asthma model

rational design from literature starting point

J. Med. Chem., Mar. 22, 2021

Genentech, South San Francisco, CA

The Genentech transient receptor potential ankyrin 1 (TRPA1) inhibitor (“compound 20”) is an ion channel inhibitor with a binding site and mechanism of action characterized by cryo-EM. Structural information…

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“Compound 20”

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this content is exclusive to
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