cryo-EM-characterized TRPA1 ion channel inh.

oral efficacy (10 mpk BID) in asthma model

rational design from literature starting point

J. Med. Chem., Mar. 22, 2021

Genentech, South San Francisco, CA

Structure of compound 20

The Genentech transient receptor potential ankyrin 1 (TRPA1) inhibitor (“compound 20”) is an ion channel inhibitor with a binding site and mechanism of action characterized by cryo-EM. Structural information…

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