© Rosalind Scientific LLC 2018-2022
© Rosalind Scientific LLC, 2018-2022
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cryo-EM-characterized TRPA1 ion channel inh.
oral efficacy (10 mpk BID) in asthma model
rational design from literature starting point
J. Med. Chem., Mar. 22, 2021
Genentech, South San Francisco, CA
The Genentech transient receptor potential ankyrin 1 (TRPA1) inhibitor (“compound 20”) is an ion channel inhibitor with a binding site and mechanism of action characterized by cryo-EM. Structural information…
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