Chemical structure of molecule compound 17a

SGK1 kinase inhibitor

preclinical activity in osteoarthritis explant model

from DFG-out virtual screening, SBDD and MPO

Journal of Medicinal Chemistry

Sanofi, Frankfurt am Main, DE

Kinase inhibitors are increasingly being explored for diseases beyond cancer. While SGK1 has been a cancer target, SGK1 has also been implicated in osteoarthritis pathology, and the Sanofi team…

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