© Rosalind Scientific LLC 2018-2022
© Rosalind Scientific LLC, 2018-2022
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venetoclax prodrug with reduced food effect
enhanced bioavailability in healthy volunteers
from venetoclax heterocycle N-alkylation
Mol. Cancer. Ther. Mar. 30, 2021
AbbVie, North Chicago, IL
The AbbVie BCL-2 inhibitor prodrug (ABBV-167) is a phosphate prodrug of venetoclax used for treatment of chronic lymphocytic leukemia (CLL). This molecule has an interesting prodrug mechanism, masking an…
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