This section contains case studies, industry highlights, minireviews, and other articles for drug discovery professionals. Check out the resources page for posters, educational content, lists of drug approvals, and more.
Scientists from GlaxoSmithKline’s Stevenage site have an excellent article in J. Med. Chem. showing that cyclopropyl pyran (CPP) groups can…
Article
4 years ago ●
4 mins read
Context. “compound 4e” (Chiesi Farmaceutici) is an inhaled p38α/β mitogen-activated protein kinase (MAPK) inhibitor being developed for lung inflammatory diseases.…
molecule
10 months ago ●
4 mins read
Modern hit-finding technologies are incredible. Dean Brown and Jonas Bostrom at AstraZeneca have a very nice review out summarizing the…
Article
5 years ago ●
10 mins read
Context. MAGLi 432 (Roche) is a novel, reversible monoacylglycerol lipase (MAGL) inhibitor. There has been increasing interest in the role…
molecule
10 months ago ●
4 mins read
BMS-986142 is a reversible BTK inhibitor with two axial stereocenters. BMS synthetic chemists were able to make >200 kilos of…
Article
5 years ago ●
4 mins read
Context. Sudapyridine (WuXi AppTec) is an oral mycobacterial ATP synthase inhibitor being developed for tuberculosis (TB). Despite the significant success…
molecule
10 months ago ●
4 mins read
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