6. BMS-986318 – BMS cyclobutene-containing FXR agonist

Small Molecules of the Month – Aug. 2021

The August edition of Small Molecules of the Month, features a recently approved, dibasic oral kallikrein inhibitor, a spirocyclobutene-containing FXR agonist, a NaV1.6 clinical candidate, a remarkably long acting RIPK2 PROTAC, and several other interesting clinical candidates. Thanks to reviewers Joachim Rudolph, Kim Huard, Jake Schwarz, Julien Lefranc, and Chris Read more…

First Disclosures of Small Molecule Drug Candidates – EFMC-ISMC 2021

By Christian Kuttruff and Julien Lefranc The first disclosures of new drug candidates are always the highlight of medicinal chemistry conferences. Six novel drug candidates were recently disclosed by European companies at the European Federation for Medicinal Chemistry International Symposium on Medicinal Chemistry (EFMC-ISMC) Conference in Basel, including a KRAS Read more…