There were 15 novel large molecule drugs approved in 2020, an increase over the 12 large molecule drugs approved in 2019. Here’s a visual list of the FDA’s 2020 large molecule drug approvals, with more details and references below. There is no significance to the order in which molecules are Read more…
The March 2021 edition of Drug Hunter‘s Small Molecules of the Month series contains several small molecule clinical candidates as well as pre-clinical small molecules with interesting structures or mechanisms. Among the highlights are LSN3318839, a molecular glue that binds both GLP-1R receptor its endogenous GLP peptide, a P-gp inhibitor Read more…
February was a packed month for interesting molecules – there were nearly 20 molecules we thought about including in this list but couldn’t fit them all. There are several clinical candidates this month including mobocertinib, an exon 20 mutant inhibitor that was recently given Breakthrough Therapy Designation by the FDA. Read more…
For the first installment of Drug Hunter’s “Small Molecules of the Month” series in 2021, we have a Kissei SGLT2 inhibitor whose lead was a metabolite found in mouse urine, a GSK integrin inhibitor that was found to trigger lysosomal degradation, and the first non-sugar OGA inhibitor derived from a Read more…
In 2020 the Drug Hunter site highlighted >150 “molecules of the month” whose structures or stories were typically published for the first time. They were selected from thousands of research articles, published by leading institutions around the world. It was incredibly hard to narrow down the selection to just one Read more…
Happy 2021! Here’s the last installment of Small Molecules of the Month for 2020. It was so hard to narrow this down to one sheet of molecules since there were so many timely publications in December. One of my favorites this month is an oral(!) ultra-long acting insulin derivative from Read more…