oral serine _-lactamase inh. prodrug
restores ceftibuten activity in model, Ph. I
hydrolysis transition state mimetic
Journal of Medicinal Chemistry
Venatorx Pharmaceuticals, Malvern, US
VNRX-7145
11. The Venatorx serine _-lactamase inhibitor VNRX-7145 is an orally bioavailable prodrug of the boronic acid-containing inhibitor VNRX-5236, and is currently in Ph. I. It demonstrates activity in vitro…