VNRX-7145

oral serine _-lactamase inh. prodrug

restores ceftibuten activity in model, Ph. I

hydrolysis transition state mimetic

Journal of Medicinal Chemistry

Venatorx Pharmaceuticals, Malvern, US

11. The Venatorx serine _-lactamase inhibitor VNRX-7145 is an orally bioavailable prodrug of the boronic acid-containing inhibitor VNRX-5236, and is currently in Ph. I. It demonstrates activity in vitro…


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