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Oct. 6, 2021

Soticlestat: A Brain-Penetrant Cholesterol 24-Hydroxylase Inhibitor


brain-penetrant CH24H inhibitor Ph. 2 for epilepsies (up to 300 mg PO QD) from SBDD Journal of Medicinal Chemistry Takeda, Fujisawa, Japan

Drug Hunter Team

The Takeda cholesterol 24-hydroxylase inhibitor, soticlestat (TAK-935, previously OV935) is a potent, highly selective, first-in-class inhibitor of the brain-specific enzyme cholesterol 24-hydroxylase (CH24H). Cholesterol 24-hydroxylase converts cholesterol to 24S-hydroxycholesterol, which acts as a positive allosteric modulator of [...]



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