brain-penetrant CH24H inhibitor

Ph. 2 for epilepsies (up to 300 mg PO QD)

from SBDD

Journal of Medicinal Chemistry

Takeda, Fujisawa, Japan

The Takeda cholesterol 24-hydroxylase inhibitor, soticlestat (TAK-935, previously OV935) is a potent, highly selective, first-in-class inhibitor of the brain-specific enzyme cholesterol 24-hydroxylase (CH24H). Cholesterol 24-hydroxylase converts cholesterol to 24S-hydroxycholesterol, which acts…

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