© Rosalind Scientific LLC 2018-2022
© Rosalind Scientific LLC, 2018-2022
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selective CDK2/4/6 inhibitor
oral agent in Ph. I/IIa for HR+ HER2- cancers
screen for CDK1/2 sel., SBDD + Free-Wilson
Journal of Medicinal Chemistry
Pfizer, San Diego, US
5. The Pfizer CDK2/4/6 inhibitor PF-60873600 is orally bioavailable with Ki values of 0.09 nM, 1.3 nM, and 0.16 nM for CDK2, CDK4, and CDK6, respectively, with lower activities…
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