highly selective NaV1.6 sodium channel inh.

entering Ph. II for seizures (100 mg TID)

arylsulfonamide class

bioRxiv

Xenon Pharmaceuticals, Burnaby, Canada

NBI-921352

The Xenon NaV1.6 Inhibitor, NBI-921352, is remarkably selective for the NaV1.6 sodium channel over other isoforms (IC50 = 51 nM, 756x vs. NaV1.1, 134X vs. NaV1.2, 276X vs. NaV1.7, >583X…


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