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Oct. 6, 2021

MK-8262: A CETP Inhibitor


potential best-in-class CETP inh. (<1 mg QD) completed Ph. I in HV; discont. as backup from anacetrapib Journal of Medicinal Chemistry Merck & Co., Kenilworth, NJ, USA

Drug Hunter Team

The Merck CETP inhibitor backup, MK-8262 , is potential best-in-class CETP inhibitor, which was only discontinued as a backup due to the success of its predecessor, anacetrapib in Ph. III. Reviewer Kim Huard thought this CETP inhibitor was a great piece of work from Merck, and is a great example how to deal with a very lipophilic binding site [...]



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