orally active covalent menin-MLL PPI inhibitor

efficacy in xenograft (300 mpk PO QD)

warhead addition to rev. inh. and opt.

Journal of Medicinal Chemistry

University of Michigan, Ann Arbor, US

M-1121

9. The University of Michigan menin-MLL inhibitor, M-1121, is a covalent protein-protein interaction inhibitor that is orally active and achieves complete tumor regression in a xenograft model (300 mpk…


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