orally active covalent menin-MLL PPI inhibitor
efficacy in xenograft (300 mpk PO QD)
warhead addition to rev. inh. and opt.
Journal of Medicinal Chemistry
University of Michigan, Ann Arbor, US
9. The University of Michigan menin-MLL inhibitor, M-1121, is a covalent protein-protein interaction inhibitor that is orally active and achieves complete tumor regression in a xenograft model (300 mpk…