oral splicing modulator (SF3b complex)
7-20 mg 21d+/7d-, Ph. I for myeloid neoplasias
from opt. of pladienolide B natural product
Leukemia
H3 Biomedicine, Cambridge, US
H3B-8800
1. The H3 Biomedicine RNA splicing modulator, H3B-8800, targets the spliceosome SF3b complex containing either wild-type (WT) or mutant SF3B1. Splicesome inhibition can induce synthetic lethality since cancer cells…