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Oct. 6, 2021

Compound 4f: A MAGL Inhibitor

"compound 4f"

oral, brain-penetrant, reversible MAGL inh. in vivo PK/PD in CNS (0.3-10 mpk PO) from HTS and SBDD Journal of Medicinal Chemistry Takeda, Fujisawa, Japan

Drug Hunter Team

The Takeda MAGL inhibitor, “compound 4f” , was selected by reviewer Joachim Rudolph . “MAGL (monoacylglycerol lipase) is implicated in neuroinflammation, and inhibitors of this enzyme are of interest as therapeutics in neurodegenerative and other neurological diseases. Most of the advanced compounds, including the clinically evaluated [...]



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