Structure of compound 18n

monocarboxylate transporter 4 inhibitor

in vivo PD but limited eff. in xenograft model

from cell-based screen and opt.

Journal of Medicinal Chemistry

Merck Healthcare KGaA, Darmstadt, Germany

The Merck KGaA MCT4 chemical probe, “compound 18n”, is a novel inhibitor of the monocarboxylate transporter MCT4. Large quantities of lactic acid need to be transported out of tumor cells…

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