Inhaled dual M3 antagonist/PDE4 inhibitor

intratracheal efficacy in model, not developed

from linking M3 antag. + PDE inh. and opt.

Journal of Medicinal Chemistry

Chiesi Farmaceutici S.p.A., Parma, IT

10. The Chiesi M3 antagonist/PDE4 inhibitor dual pharmacology molecule, compound 92a, is an inhaled compound intended for pulmonary diseases. Both M3 and PDE4 are clinically validated targets for COPD…

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