oral FXR agonist for NASH

robust in vivo PD, phase I HV study withdrawn

from prior FXR agonists

ACS Med. Chem. Lett

Bristol Myers Squibb, Princeton, NJ, USA

The BMS spirocyclobutene-containing FXR agonist, BMS-986318, appears to have been intended as a clinical candidate, but was withdrawn from a planned Ph. I study. The molecule exhibits potent in vitro and in…

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