CNS-penetrant non-zinc binding ATX inhibitor

oral PK/PD and efficacy in inflamm. pain model

from phosphonic acid hit from S1P library

ACS Medicinal Chemistry Letters

Biogen Inc., Cambridge, US

BIO-32546

The Biogen compound BIO-32546 is a potent (IC50 = 1 nM), selective, oral, non-zinc-binding reversible autotaxin (ATX) inhibitor, and is an interesting example of a relevantly large brain-penetrant zwitterion.…


get free samples and a Premium trial

Premium members get access to our library of hundreds of in-depth reviews on key molecules, ten new reviews each month, novel drug approval coverage, drug discovery company updates, and more: