CNS-penetrant non-zinc binding ATX inhibitor

oral PK/PD and efficacy in inflamm. pain model

from phosphonic acid hit from S1P library

ACS Medicinal Chemistry Letters

Biogen Inc., Cambridge, US

The Biogen compound BIO-32546 is a potent (IC50 = 1 nM), selective, oral, non-zinc-binding reversible autotaxin (ATX) inhibitor, and is an interesting example of a relevantly large brain-penetrant zwitterion.…

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