This page contains Drug Hunter’s practical PK calculators useful for day-to-day drug discovery, including a PK unit converter such as for uM to ng/mL unit conversion, an animal study requirement calculator for how much material to synthesize in preparation for animal studies, and a simple human equivalent dose estimator.
Who doesn’t find themselves periodically scratching their heads at the units other people choose to report their data in? If you’re a chemist, it’s annoying to find a chart in mass units (g/mL) when you care about concentration (M). If you’re the person planning or weighing out the material for the actual PK studies, it probably doesn’t help when your chemist gives you a target concentration and a chemical structure that you couldn’t distinguish from chickenwire if you tried.
Here are some basic calculators to start. Hope this makes your life a little easier. You may also find our PK reference table (PK Cheat Sheet) useful for this.
Having a brain freeze trying to read PK/PD or efficacy results in ng/mL? Check this calculator!
Planning a study and need a quick guesstimate for how much material you need? Check this calculator!
Have a dose from animal studies and want to guesstimate what the human equivalent dose would be using simple allometric scaling assumptions? Check this calculator! This does not factor in any kind of cross-species biochemical differences.
These calculators were suggested and mapped out thanks to Dr. Berenger Biannic.
About Berenger Biannic
Dr. Berenger Biannic is an Associate Director in Chemistry at ESSA Pharma working on the next generation of treatment for prostate cancer patients. After a postdoc in the Trost Lab at Stanford University, he started his industrial career as a drug discovery scientist at FLX Bio (now RAPT Therapeutics) and led the chemistry efforts on an immuno-oncology program. Berenger joined AbbVie in 2018 and worked on multiple oncology programs in the bRo5 chemical space until 2021. Organic chemist by training, Berenger is passionate about pharmacology and how it helps chemists to design high quality clinical candidates. His free time is devoted to making sure his two young boys don’t injure themselves, cooking exotic food and watching the Office over and over.