MAGLi 43 Chemical Structure, CNS penetrant, intraperitoneal, reversible MAGL inh - Roche, Basel, CH

CNS penetrant, intraperitoneal, reversible MAGL inh

in vivo target engagement in brain but lack of efficacy

from opt. of a screening hit

bioRxiv

Roche, Basel, CH

Context. MAGLi 432 (Roche) is a novel, reversible monoacylglycerol lipase (MAGL) inhibitor. There has been increasing interest in the role of inflammation and blood-brain barrier dysfunction in neurology. The…


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