CNS penetrant, intraperitoneal, reversible MAGL inh
in vivo target engagement in brain but lack of efficacy
from opt. of a screening hit
bioRxiv
Roche, Basel, CH
MAGLi 43
Context. MAGLi 432 (Roche) is a novel, reversible monoacylglycerol lipase (MAGL) inhibitor. There has been increasing interest in the role of inflammation and blood-brain barrier dysfunction in neurology. The…