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“Compound (P)-14″ is a PI3K beta-isoform selective lipid kinase inhibitor. While the compound is potent and has excellent oral PK in higher species, significant irreversible toxicity was observed in a tox. study, and the chemical series was discontinued. It’s always great when organizations disclose tox. findings to educate the community. Interestingly the molecule has a significant barrier to rotation around the benzimidazole ring and can be isolated as a stable atropisomer.