Anh Tran

Principal Scientist and Medicinal Chemistry Team Leader

Anh is currently a Principal Scientist and Medicinal Chemistry Team Leader at Amgen, in Thousand Oaks, and has worked on several early-stage drug discovery programs mainly in the TPD space. Anh is an active writer for the annual ACS Medicinal Chemistry Reviews and a regular contributor to the ACS MEDI Division and GRC Medicinal Chemistry future program planning efforts.

Drug-Induced Liver Injury: A Medicinal Chemist’s Perspective

DILI is a leading cause of acute liver failure, accounting for half of these cases and often resulting in drug withdrawals. Understanding and managing DILI risk as a medicinal chemist involves exploring the intricate interplay among properties and structural features. In this article, we provide a medicinal chemist's perspective on the current understanding of DILI mechanisms, highlight cutting-edge assay developments for a holistic assessment, and discuss strategies for predicting DILI risks.

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