Two past Molecules of the Month inductees had significant updates recently, showing they’re still moving forward: upacicalcet This September ‘22 Molecule of the Month is an IV calcium-sensing receptor (CaSR) agonist first identified in flavor studies of peptides. It is already approved in Japan for secondary hyperparathyroidism (SHPT), and [...]

The final set of Molecules of the Month for 2022 is out, and now it’s time to nominate your favorite molecules for 2022’s Molecules of the Year! Nominees should have either been first disclosed in 2022 or had a major new update in 2022 (e.g. clinical trial readout, publication, business transaction, approval). The molecule must have a [...]

You’ve read about the top 10 molecules with publications from August, but what about the ones we found interesting that didn’t make it into Molecules of the Month? There were five runners-up from August 2022, including: a highly selective, dihydropyrimidinone-based CSF1R switch-control kinase inhibitor a non-competitive, allosteric CXCR1/2 [...]

Readers have been asking for more molecules, so we started a new feature that highlights a few of the molecules we liked that didn’t make it into Molecules of the Month. There were six runners-up this month, including an orally available ALK2 inhibitor and a direct AMPK activator for X-linked adrenoleukodystrophy. You can read more about all [...]

Readers have been asking for more molecules, so this month, we’re starting a new feature that will highlight a few of the molecules we liked that didn’t make it into Molecules of the Month. There were six runners-up this month, including an orally bioavailable, brain penetrant inhibitor of PAAN/MIF, and a STING agonist discovered using [...]

We've just published the final set of Molecules of the Month for 2021, and now it's time to nominate your favorite molecules for 2021's Molecules of the Year! Nominees should have either been first disclosed in 2021 or had a major new update in 2021 (e.g. clinical trial readout, publication, business transaction, approval). The molecule must [...]