drughunter.com
< 1 minute read
Sep. 10, 2024

Tackling MedChem Bias One Functional Group at a Time

drughunter.com
Drug Hunter Team
Loading...

twitterlinkedinemail

Other articles you may be interested in

Molecules on the Move: Reversible BTKi in MS, THR-beta Agonist in NASH, and More

This article compiles recent high-profile clinical readouts and related news with small molecules of general interest and structures where they are available. Targets and indications discussed in this article include BTK for MS, Axl, TYRO3, and Mer for oncology, HIF prolyl-hydroxylase in anemia, ET/AT in nephrology, a JAK2 inhibitor for myelofibrosis, and THR-beta in NASH. [...]

Where Do Recent Small Molecule Clinical Candidates Come From?

Modern hit-finding technologies are incredible. Dean Brown and Jonas Bostrom at AstraZeneca have a very nice review out summarizing the hit-finding strategies for 66 clinical candidates published from 2016-2017. Some highlights include a clinical candidate from DNA-encoded libraries at GSK, the discovery of an RNA-binding drug candidate by [...]

Advancing Macrocycles in Drug Discovery

In this Flash Talk, Katarina Leftheris highlights how advances in our understanding of ADME requirements, screening technologies, formulations development and computational modeling helped macrocycles back on the center stage of the industry.

As part of our Flash Talk webinar series, we present a PDF of Katarina Letheris'slide deck, entitled "Advancing Macrocycles in Drug Discovery". Check out the recording of the talk on our Drug Hunter YouTube channel.

Small Molecules Evolve

Small molecule drugs make up most of the drugs we take conveniently as pills, including painkillers like ibuprofen (Advil), antibiotics like penicillin and amoxicillin, or cholesterol-lowering drugs like atorvastatin (Lipitor). The biotechnology revolution allowed scientists to create drugs through genetic engineering and related biological processes, creating a new category of drugs known as “biologics.”...

The Chemist's Playbook: Impactful Bioisosteres for Modern Drug Design

As part of our Flash Talk webinar series, we present a PDF of Nicholas Meanwell's slide deck entitled "The Chemist's Playbook: Impactful Bioisosteres for Modern Drug Design". Check out the recording of the talk on our Drug Hunter YouTube channel.