Recent Highlights in Covalent Drug Discovery

In Wednesday’s Flash Talk webinar, we covered recent highlights in covalent drug discovery, with lots of great questions from the audience. The webinar and recording are available below to everyone thanks to our sponsor, Revvity Signals, and the slides are available for download to Premium members at the bottom.

The talk covered:

1. Covalent drugs that break the toxicity stigma

2. Case studies from notable recent covalent molecules

3. Covalent drugs to watch

Some of the highlights mentioned in the talk include:

1. JAK3 inhibitor from Pfizer, ritlecitinib

2. FGFR2 selective inhibitor from Relay, RLY-4008

3. KRASG12C glue from Revolution Medicine, RMC-6291

4. HbS inhibitor from Pfizer and GBT, voxelotor

5. Mpro inhibitor from Pfizer, nirmatrelvir

6. A diazoketone from JHU/Dracen, sirpiglenastat

7. MK2 inhibitor with a SNAr-based warhead from BMS/Celgene, CC-99677

8. KRASG12R inhibitor from Shokat, compound 3

Recent Highlights in Covalent Drug Discovery Flash Talk:

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