Patent Pulse: A Spotlight on Recent Highlights from Small Molecule Patents
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Computational Partnership in Small Molecule Drug Discovery
The real magic happens when chemists can integrate computational models into their assay cascades, thanks to trust in their predictions. To get there, grounding computational predictions in physics and experimental reality makes all the difference. In this article, Abba E. Leffler, Ph.D. from Schrödinger tells us about: How to make [...]
Advancing Macrocycles in Drug Discovery
In this Flash Talk, Katarina Leftheris highlights how advances in our understanding of ADME requirements, screening technologies, formulations development and computational modeling helped macrocycles back on the center stage of the industry.
As part of our Flash Talk webinar series, we present a PDF of Katarina Letheris'slide deck, entitled "Advancing Macrocycles in Drug Discovery". Check out the recording of the talk on our Drug Hunter YouTube channel.
Molecules on the Move: Reversible BTKi in MS, THR-beta Agonist in NASH, and More
This article compiles recent high-profile clinical readouts and related news with small molecules of general interest and structures where they are available. Targets and indications discussed in this article include BTK for MS, Axl, TYRO3, and Mer for oncology, HIF prolyl-hydroxylase in anemia, ET/AT in nephrology, a JAK2 inhibitor for myelofibrosis, and THR-beta in NASH. [...]
Roles of the Chloro and Methoxy Groups in Drug Discovery
In this Flash Talk, Yoshihiro Ishihara discussed the beneficial effects of chloro and methoxy substituents on intermolecular interactions, as well as the unique advantages and disadvantages of employing these substituents in drug discovery.
As part of our Flash Talk webinar series, we present a PDF of Yoshihiro Ishihara's slide deck and full text questions and answers from his talk, entitled "Roles of the Chloro and Methoxy Groups in Drug Discovery." Check out the recording of the talk on our Drug Hunter YouTube channel.
The Chemist's Playbook: Impactful Bioisosteres for Modern Drug Design
As part of our Flash Talk webinar series, we present a PDF of Nicholas Meanwell's slide deck entitled "The Chemist's Playbook: Impactful Bioisosteres for Modern Drug Design". Check out the recording of the talk on our Drug Hunter YouTube channel.
