6. BMS-986318 – BMS cyclobutene-containing FXR agonist

Small Molecules of the Month – Aug. 2021

The August edition of Small Molecules of the Month, features a recently approved, dibasic oral kallikrein inhibitor, a spirocyclobutene-containing FXR agonist, a NaV1.6 clinical candidate, a remarkably long acting RIPK2 PROTAC, and several other interesting clinical candidates. Thanks to reviewers Joachim Rudolph, Kim Huard, Jake Schwarz, Julien Lefranc, and Chris Read more…

Small Molecules of the Month – Jun. 2021

June’s edition of Small Molecules of the Month features a natural product-derived RNA splicing modulator, a mTORC1-selective “bi-steric” inhibitor, numerous low-dose clinical candidates and several unusual chemical motfs (e.g. pyridine N-oxide, sulfinylamine, boronic acid).  Links to articles, PDF download, and full summaries below. The H3 Biomedicine RNA splicing modulator, H3B-8800, Read more…