Topliss Cheat Sheets

This guest post introduces the Topliss schemes for analog synthesis, illustrates when they might be useful, and provides easy-to-use “cheat sheets” of the original schemes. Imagine you’re on a new project that has just conducted a chemical screen on a novel target, and you’re excited to see a few micromolar Read more…

Year of the Chimera PROTAC

2020, Year of the Chimera?

This post briefly introduces chimeric molecules and companies working on them, contains a list of 10 recent “hot” papers in this field, and some predictions for where chimeras might head. It’s Chinese New Year time, which means a significant part of the global biopharma supply chain has ground to a Read more…