In April’s edition of Small Molecules of the Month, we have several fascinating molecules including a tri-complex KRAS-ON inhibitor from Revolution Medicines, a targeted protein stabilizer from a Berkeley/Novartis collaboration, and an RNA-modifying enzyme inhibitor from Storm/Cambridge.

A slide deck with more details about each molecule are available here.

RM-018
GDC-0334
BAY 1101042 (runcaciguat)
AG-270
NJH-2-057
basmisanil
STM-2457
compound 28
VT-104
CB-5083
compound 20p
SHR168442
GNE-9815
ABD957
KRAS(G12C)
TRPA1
sGC
MAT2A
DeltaF508-CFTR
GABA-A-α5
METTL3
MAT2A
TEAD1
P97/VCP (PDE6 off-target)
FXR/TGR5
RORγ
RAF (BRAF/CRAF)
ABHD17
Antagonist
Activator
Inhibitor
DUBTAC
Modulator
Agonist

Small Molecules of the Month - Apr. 2021

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Looking for more details?

Links to Articles:

  1. RM-018
  2. GDC-0334
  3. BAY 1101042 (runcaciguat)
  4. AG-270
  5. NJH-2-057
  6. basmisanil
  7. STM-2457
  8. compound 28
  9. VT-104
  10. CB-5083
  11. compound 20p
  12. SHR168442
  13. GNE-9815
  14. ABD957

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